In vivo effects of adding singular or combined anti-oxidative vitamins and/or minerals to diets on the immune system of tilapia ( Oreochromis hybrids) peripheral blood monocyte-derived, anterior kidney-derived, and spleen-derived macrophages

Macrophage function is an important factor for resistance to infection and anti-oxidative vitamins and minerals can affect how macrophages function in fish. We report the in vivo effect of adding singular or combined vitamins (A, C, and E) and/or minerals (Se, Zn, Cu, Mn, and Fe) in diets on the imm...

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Bibliographic Details
Published in:Veterinary Immunology and Immunopathology 2007-01, Vol.115 (1), p.87-99
Main Authors: Hung, Shao-Wen, Tu, Ching-Yu, Wang, Way-Shyan
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Ascorbic Acid - pharmacology
Cell Proliferation - drug effects
Diet
Dose-Response Relationship, Drug
In vivo
Kidney - immunology
Macrophage
Macrophages - immunology
Minerals
Minerals - pharmacology
Monocytes - immunology
Muramidase - biosynthesis
Nitric Oxide - biosynthesis
Oreochromis
Spleen - immunology
Superoxides - metabolism
Tilapia
Tilapia - immunology
Vitamin A - pharmacology
Vitamin E - pharmacology
Vitamins
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Summary:Macrophage function is an important factor for resistance to infection and anti-oxidative vitamins and minerals can affect how macrophages function in fish. We report the in vivo effect of adding singular or combined vitamins (A, C, and E) and/or minerals (Se, Zn, Cu, Mn, and Fe) in diets on the immune system of tilapia ( Oreochromis hybrids) peripheral blood monocyte-derived, anterior kidney-derived, and spleen-derived macrophages. An optimal dose of vitamins and/or minerals in diets increased macrophage proliferation and protective activity, maintained macrophage viability, increased body weight and length, and increased lysozyme activity, however, at improper doses and combinations of vitamins or minerals a decrease was observed. Furthermore, vitamins and/or minerals at any doses and combinations in diets decreased superoxide and nitric oxide production. Therefore, appropriate doses and combinations of vitamins and/or minerals in diets may increase tilapia macrophages immunity.
ISSN:0165-2427
1873-2534
1365-2567
DOI:10.1016/j.vetimm.2006.09.004