Minor physical anomalies across ethnic groups in a first episode psychosis sample

Abstract Minor physical anomalies (MPAs) are more prevalent amongst individuals with psychosis, supporting a neurodevelopmental model for psychotic disorders. The aim of this study was to investigate the possibility that neurodevelopmental adversity contributes to the excess of psychosis found in so...

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Bibliographic Details
Published in:Schizophrenia research 2007-01, Vol.89 (1), p.86-90
Main Authors: Dean, K, Dazzan, P, Lloyd, T, Morgan, C, Morgan, K, Doody, G.A, Hutchinson, G, Orr, K, Jones, P.B, Murray, R.M, Fearon, P
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Affective Disorders, Psychotic - diagnosis
Affective Disorders, Psychotic - epidemiology
Affective Disorders, Psychotic - ethnology
African Continental Ancestry Group - psychology
Biological and medical sciences
Bipolar Disorder - diagnosis
Bipolar Disorder - epidemiology
Bipolar Disorder - ethnology
Comorbidity
Congenital Abnormalities - diagnosis
Congenital Abnormalities - epidemiology
Congenital Abnormalities - ethnology
Cross-Sectional Studies
England
Ethnicity
European Continental Ancestry Group - psychology
Female
First onset
Humans
Incidence
Male
Medical sciences
Middle Aged
Minor physical anomalies
Neurodevelopment
Other psychotic disorders
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Psychosis
Psychotic Disorders - diagnosis
Psychotic Disorders - epidemiology
Psychotic Disorders - ethnology
Reference Values
Risk Factors
Schizophrenia - diagnosis
Schizophrenia - epidemiology
Schizophrenia - ethnology
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Summary:Abstract Minor physical anomalies (MPAs) are more prevalent amongst individuals with psychosis, supporting a neurodevelopmental model for psychotic disorders. The aim of this study was to investigate the possibility that neurodevelopmental adversity contributes to the excess of psychosis found in some ethnic groups in the UK. Subjects with first onset psychosis and healthy neighbourhood controls were enrolled in the ÆSOP study in South East London and Nottingham between 1997 and 1999. MPA rates were estimated in four broad ethnic groupings (White, African Caribbean, Black African and Other). Patients ( n = 245) had a higher mean total MPA score than healthy controls ( n = 158). This held true across each of the four ethnic groupings. The results of this study suggest that neurodevelopmental factors play a role in the aetiology of psychosis across all ethnic groups.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2006.08.019