Ki-67, p53, ER Receptors, Ploidy and S Phase as Long-Term Prognostic Factors in T1 Node-Negative Breast Cancer

• Published in: Tumor biology 2007-01, Vol.28 (1), p.45-51
• Main Authors: Railo, Mikael, Lundin, Johan, Haglund, Caj, von Smitten, Karl, Nordling, Stig
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Aneuploidy; Breast Neoplasms - diagnosis; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; DNA, Neoplasm - genetics; Female; Gene Expression Regulation, Neoplastic; Humans; Ki-67 Antigen - genetics; Ki-67 Antigen - metabolism; Lymph Nodes - pathology; Middle Aged; Predictive Value of Tests; Prognosis; Receptors, Estrogen - genetics; Receptors, Estrogen - metabolism; Research Article; S Phase - genetics; Survival Analysis; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1159/000097702

Background: The aim of the present study was to evaluate a series of biomarkers with regard to long-term prognostic value in patients with T1 (≤2 cm) node-negative breast cancer. Method: The prognostic value of Ki-67, p53, oestrogen receptor (ER) immunohistochemical labelling, flow-cytometric S phase fraction and ploidy was evaluated in 212 patients with pT1N0M0 breast cancer. The median follow-up time was 15.9 years (range 0.2–27.2 years). Results: In an analysis of breast cancer-specific survival up to 5 years, high Ki-67 (≧10%; p = 0.002), high p53 (≧20%; p = 0.01), negative ER (3%) and high p53 (≧20%) were compared to patients with other combinations (p = 0.03). Conclusion: According to the results of our series, it seems that several prognostic markers which are associated with short-term survival (≤5 years) in pT1N0M0 breast cancer may not be significant predictors of long-term (>15 years) breast cancer-specific survival.