The blu Blur: Mutation of a Vesicular Glutamate Transporter Reduces the Resolution of Zebrafish Vision

Vesicular transporters mediate the packaging of neurotransmitters into synaptic vesicles and can therefore control the amount of neurotransmitter released into the synaptic cleft. In this issue of Neuron, Smear et al. demonstrate that mutation of a vesicular glutamate transporter (Vglut) found in th...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2007-01, Vol.53 (1), p.4-6
Main Authors: Demas, Jay, Cline, Hollis T.
Format: Article
Language:English
Subjects:
Anatomy & physiology
Animals
Behavior
Brassica
Danio rerio
Defects
Drosophila
Eyes & eyesight
Gene expression
Glutamic Acid - metabolism
Mutation
Mutation - genetics
Neural Pathways - cytology
Neural Pathways - metabolism
Neural Pathways - physiopathology
Retinal Ganglion Cells - metabolism
Retinal Ganglion Cells - ultrastructure
Swimming
Synaptic Transmission - genetics
Transmitters
Vesicular Glutamate Transport Proteins - genetics
Vision Disorders - genetics
Vision Disorders - metabolism
Vision Disorders - physiopathology
Vision, Ocular - genetics
Zebrafish
Zebrafish - anatomy & histology
Zebrafish - metabolism
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Summary:Vesicular transporters mediate the packaging of neurotransmitters into synaptic vesicles and can therefore control the amount of neurotransmitter released into the synaptic cleft. In this issue of Neuron, Smear et al. demonstrate that mutation of a vesicular glutamate transporter (Vglut) found in the retinal ganglion cells (RGCs) of zebrafish alters both the synaptic transmission and connectivity between RGCs and their targets, limiting the transfer of visually evoked activity from RGCs and degrading behaviors that depend on high-acuity vision.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2006.12.019