Interstitial lung disease in a patient with antisynthetase syndrome and no myositis

Interstitial lung disease in patients with antisynthetase syndrome and no evidence of myositis is rare and may precede other disease manifestations. We report a patient who initially presented with symptoms primarily related to lung involvement. The diagnosis of the antisynthetase syndrome without m...

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Bibliographic Details
Published in:Clinical rheumatology 2007-01, Vol.26 (1), p.108-111
Main Authors: Plastiras, Sotiris C, Soliotis, Fotini C, Vlachoyiannopoulos, Panayiotis, Tzelepis, George E
Format: Article
Language:English
Subjects:
Adult
Amino Acyl-tRNA Synthetases - immunology
Antibodies, Antinuclear - blood
Antibodies, Antinuclear - immunology
Autoantibodies
Autoantibodies - blood
Autoantibodies - immunology
Diagnosis
Exanthema
Humans
Inflammatory diseases
Lung diseases
Lung Diseases, Interstitial - immunology
Lung Diseases, Interstitial - pathology
Male
Musculoskeletal diseases
Myositis
Myositis - immunology
Myositis - pathology
Patients
Syndrome
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Description
Summary:Interstitial lung disease in patients with antisynthetase syndrome and no evidence of myositis is rare and may precede other disease manifestations. We report a patient who initially presented with symptoms primarily related to lung involvement. The diagnosis of the antisynthetase syndrome without myositis was made many months later when he developed a characteristic hand rash (mechanic's hands), which was confirmed by positive antibodies to Jo-1. With treatment, both the hand rash and the interstitial lung disease improved. Antisynthetase syndrome should be considered in patients presenting with interstitial lung disease with no evidence of myositis. Appropriate laboratory testing with measurement of specific autoantibodies may help in the early diagnosis and treatment of the syndrome.
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-005-0111-3