Risk Factors for Coronary Artery Disease in Patients With Elevated High-Density Lipoprotein Cholesterol

High high-density lipoprotein (HDL) levels protect against coronary artery disease (CAD) development. We hypothesized that patients with CAD and high HDL levels would have higher prevalence of other CAD risk factors compared with patients with CAD and normal HDL. We identified 41,982 patients from a...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2007, Vol.99 (1), p.1-4
Main Authors: DeFaria Yeh, Doreen, MD, Freeman, Mason W., MD, Meigs, James B., MD, MPH, Grant, Richard W., MD, MPH
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Boston - epidemiology
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Case-Control Studies
Cholesterol
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Coronary Artery Disease - blood
Coronary Artery Disease - complications
Coronary Artery Disease - epidemiology
Coronary heart disease
Cross-Sectional Studies
Diabetes Mellitus
Disorders of blood lipids. Hyperlipoproteinemia
Female
Heart
Humans
Hypercholesterolemia - blood
Hypercholesterolemia - complications
Hypertension
Logistic Models
Male
Medical sciences
Metabolic diseases
Middle Aged
Obesity
Prevalence
Proteins
Risk Factors
Smoking
Triglycerides - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:High high-density lipoprotein (HDL) levels protect against coronary artery disease (CAD) development. We hypothesized that patients with CAD and high HDL levels would have higher prevalence of other CAD risk factors compared with patients with CAD and normal HDL. We identified 41,982 patients from a single center with normal levels (40 to 60 mg/dl in men, 50 to 70 mg/dl in women) or high HDL levels (≥70 mg/dl in men, ≥80 mg/dl in women) when last measured between January 2000 and April 2004. From this overall population, we characterized a cohort of 1,610 patients with CAD, including 98 patients with high HDL levels. We measured prevalence of traditional CAD risk factors by comparing these 98 patients with patients with CAD and normal HDL levels (n = 1,512). We performed manual chart review in patients (n = 196) matched 1:1 by age, gender, and HDL level to obtain further detail with regard to differences in family history and lifestyle factors. In patients with CAD, those with high HDL levels (98 of 1,610, 6.1%) were of similar age (71.1 vs 69.6 years, p = 0.23), had similar prevalence of hypertension (78.6% vs 88.7%, p = 0.30), lower levels of low-density lipoprotein (85.3 vs 90.9 mg/dl, p = 0.04) and triglycerides (87.1 vs 141.2 mg/dl, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2006.07.053