Effects of cardioversion of atrial fibrillation on endothelial function in hypertension or diabetes

Background  Cardioversion (CV) to sinus rhythm corrects endothelial dysfunction secondary to atrial fibrillation (AF). As AF often complicates hypertension and diabetes (disorders associated with impaired endothelial function) the study probed whether these comorbidities to AF produced an additive e...

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Bibliographic Details
Published in:European journal of clinical investigation 2007-01, Vol.37 (1), p.26-34
Main Authors: Guazzi, M., Belletti, S., Lenatti, L., Bianco, E., Guazzi, M. D.
Format: Article
Language:English
Subjects:
Arrhythmias
Atrial Fibrillation - physiopathology
Atrial Fibrillation - therapy
Biological and medical sciences
Blood Pressure - physiology
Cardiac dysrhythmias
Cardiology. Vascular system
diabetes
Diabetic Angiopathies - physiopathology
Diabetic Angiopathies - therapy
Electric Countershock - methods
endothelium
Endothelium, Vascular - physiopathology
Female
Follow-Up Studies
General aspects
Heart
Heart Rate - physiology
Humans
hypertension
Hypertension - complications
Hypertension - physiopathology
Male
Medical sciences
Middle Aged
Treatment Outcome
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Summary:Background  Cardioversion (CV) to sinus rhythm corrects endothelial dysfunction secondary to atrial fibrillation (AF). As AF often complicates hypertension and diabetes (disorders associated with impaired endothelial function) the study probed whether these comorbidities to AF produced an additive effect and to what extent CV might be advantageous. Materials and methods  Brachial artery flow‐mediated dilatation (FMD) was evaluated before and after CV in 17 lone AF patients (group 1), 16 patients with AF + hypertension (group 2) and 17 patients with AF + diabetes type II (group 3), while in supine and head‐up tilting (HUT) positions, as this is when endothelial vasodilation is emphasized as a counterbalance to neurogenic vasoconstriction. Results  After 2 weeks, CV in group 1 increased (P 
ISSN:0014-2972
1365-2362
DOI:10.1111/j.1365-2362.2007.01744.x