Frequency of CYP2D610 and 14 Alleles and their Influence on the Metabolic Activity of CYP2D6 in a Healthy Chinese Population

To study the frequency of CYP2D6*10 and *14 alleles in a healthy Chinese population, and the influence of these two alleles on the metabolic activity of CYP2D6. CYP2D6*10 and *14 genotypes of 295 healthy Chinese subjects were determined using a tetra‐primer method and allele‐specific amplification....

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2007-01, Vol.81 (1), p.95-98
Main Authors: Cai, WM, Chen, B, Zhang, WX
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group
Biological and medical sciences
China
Cytochrome P-450 CYP2D6 - genetics
Cytochrome P-450 CYP2D6 - metabolism
Dextromethorphan - pharmacokinetics
Female
Gene Frequency
Genotype
Humans
Male
Medical sciences
Pharmacology. Drug treatments
Phenotype
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Summary:To study the frequency of CYP2D6*10 and *14 alleles in a healthy Chinese population, and the influence of these two alleles on the metabolic activity of CYP2D6. CYP2D6*10 and *14 genotypes of 295 healthy Chinese subjects were determined using a tetra‐primer method and allele‐specific amplification. CYP2D6 phenotypes of 131 subjects were determined using dextramethorphan as probe drug. There were 10 subjects with a *14 allele, including one homozygous for *14. The gene frequency of *10 and *14 alleles were 55.8 and 1.8%, respectively. The metabolic ratio (MR) of dextramethorphan in 131 subjects was 0.032±0.106. The MR of *1/*1, *1/*10, *10/*10, *1/*14, *10/*14, and *14/*14 groups were 0.007±0.012, 0.009±0.010, 0.042±0.029, 0.093, 0.11, and 1.186, respectively. The MR of subjects with *14 allele was higher than those of *1/*1, *1/*10, or *10/*10 groups (P
ISSN:0009-9236
1532-6535
DOI:10.1038/sj.clpt.6100015