Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias

The synthesis and evaluation of a series of thiazolidine based blockers of human Kv1.5 is described. Blockade of the Kv1.5 ion channel is a potentially atrial-selective avenue for the treatment of atrial fibrillation and atrial flutter. The development and biological evaluation of a series of thiazo...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2007, Vol.17 (1), p.282-284
Main Authors: Jackson, Chris M., Blass, Benjamin, Coburn, Keith, Djandjighian, Laurent, Fadayel, Gina, Fluxe, Andrew J., Hodson, Steven J., Janusz, John M., Murawsky, Michael, Ridgeway, James M., White, Ronald E., Wu, Shengde
Format: Article
Language:English
Subjects:
Animals
Anti-Arrhythmia Agents - chemistry
Anti-Arrhythmia Agents - pharmacology
Atrial fibrillation
Atrial Fibrillation - drug therapy
Atrial Flutter - drug therapy
Atrial-selective
Human Kv1.5
Humans
Kv1.5 Potassium Channel - antagonists & inhibitors
Potassium channel
Potassium Channel Blockers - chemical synthesis
Potassium Channel Blockers - chemistry
Potassium Channel Blockers - pharmacology
Rats
Thiazolidine
Thiazolidines - chemical synthesis
Thiazolidines - chemistry
Thiazolidines - pharmacology
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Summary:The synthesis and evaluation of a series of thiazolidine based blockers of human Kv1.5 is described. Blockade of the Kv1.5 ion channel is a potentially atrial-selective avenue for the treatment of atrial fibrillation and atrial flutter. The development and biological evaluation of a series of thiazolidine-based blockers of Kv1.5 is described.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.07.007