Impact of nonmyeloablative conditioning regimens on the occurrence of pure red cell aplasia after ABO‐incompatible allogeneic haematopoietic stem cell transplantation

Background and Objectives  In the setting of major ABO‐incompatible allogeneic haematopoietic stem cell transplantation (HSCT), pure red cell aplasia (PRCA) is linked to the persistence of host residual plasma cells secreting antidonor isohaemagglutinins (HA) after transplantation. There are conflic...

Full description

Saved in:
Bibliographic Details
Published in:Vox sanguinis 2007-01, Vol.92 (1), p.85-89
Main Authors: Malfuson, J.‐V., Amor, R. B., Bonin, P., Rodet, M., Boccaccio, C., Pautas, C., Kuentz, M., Cordonnier, C., Noizat‐Pirenne, F., Maury, S.
Format: Article
Language:English
Subjects:
ABO Blood-Group System - adverse effects
ABO compatibility
Adult
allogeneic haematopoietic stem cell transplantation
Delayed Graft Function
Female
Graft vs Host Disease
Hemagglutinins - immunology
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Male
Middle Aged
nonmyeloablative conditioning regimen
pure red cell aplasia
Red-Cell Aplasia, Pure - etiology
Transplantation Conditioning - adverse effects
Transplantation Conditioning - methods
Transplantation, Homologous - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Objectives  In the setting of major ABO‐incompatible allogeneic haematopoietic stem cell transplantation (HSCT), pure red cell aplasia (PRCA) is linked to the persistence of host residual plasma cells secreting antidonor isohaemagglutinins (HA) after transplantation. There are conflicting results regarding the impact of the intensity of conditioning regimen on the occurrence of PRCA after major ABO‐mismatched HSCT. Material and Methods  To address this question, we compared two cases occurring after nonmyeloablative (NMA) and myeloablative (MA) HSCT and reviewed previous cases reported in the NMA setting. Results and Conclusions  We observed a delayed disappearance of antidonor HAs in the NMA setting, associated to a more prolonged period of red blood cells transfusion dependence than in the MA setting. In our case as in several others, the disappearance of antidonor HAs and resolution of PRCA were observed after reinforcement of the graft‐versus‐host effect (i.e. immunosuppression removal or donor leukocytes infusion).
ISSN:0042-9007
1423-0410
DOI:10.1111/j.1423-0410.2006.00865.x