Effect of long-term orlistat treatment on serum levels of advanced glycation end-products in women with polycystic ovary syndrome

Summary Background  Women with polycystic ovary syndrome (PCOS) exhibit elevated serum advanced glycation end‐products (AGE) compared with healthy subjects. Short‐term administration of orlistat has been shown to reduce the postmeal increase in serum AGE levels in women with PCOS and in controls. Ob...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2007-01, Vol.66 (1), p.103-109
Main Authors: Diamanti-Kandarakis, Evanthia, Katsikis, Ilias, Piperi, Christina, Alexandraki, Krystallenia, Panidis, Dimitrios
Format: Article
Language:English
Subjects:
Adult
Anti-Obesity Agents - administration & dosage
Anti-Obesity Agents - therapeutic use
Biological and medical sciences
Blood Glucose - analysis
Body Mass Index
Case-Control Studies
Diet
Drug Administration Schedule
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Glycation End Products, Advanced - blood
Humans
Insulin - blood
Lactones - administration & dosage
Lactones - therapeutic use
Linear Models
Lipase - antagonists & inhibitors
Medical sciences
Obesity - blood
Obesity - diet therapy
Obesity - drug therapy
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - diet therapy
Polycystic Ovary Syndrome - drug therapy
Sex Hormone-Binding Globulin - analysis
Testosterone - blood
Time Factors
Vertebrates: endocrinology
Waist-Hip Ratio
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Summary:Summary Background  Women with polycystic ovary syndrome (PCOS) exhibit elevated serum advanced glycation end‐products (AGE) compared with healthy subjects. Short‐term administration of orlistat has been shown to reduce the postmeal increase in serum AGE levels in women with PCOS and in controls. Objective  To evaluate the long‐term effect of orlistat and a low‐calorie diet on serum AGE levels, and on the hormonal and metabolic profile of obese PCOS and normal women. Design  A clinical trial of 6 months of orlistat administration with an energy‐restricted diet [basic metabolic rate (BMR) 600 kcal/day] in all subjects. Subjects  Twenty‐nine women with PCOS [aged 27·52 ± 5·77 years; body mass index (BMI) 35·43 ± 5·31 kg/m2] and 18 controls (aged 32·06 ± 5·64 years; BMI 36·39 ± 6·47 kg/m2). Measurements  Serum AGE levels (U/ml), hormonal and metabolic profile. Results  PCOS and controls did not differ in BMI (P = 0·58), waist‐to‐hip ratio (WHR) (P = 0·44), fasting insulin concentration (P = 0·45) and glucose‐to‐insulin ratio (GIR) (P = 0·34). PCOS women exhibited statistically higher AGE (P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2006.02693.x