Structure–activity delineation of quinones related to the biologically active Calothrixin B

The biological activities of Calothrixin B and six related analogues against three cell lines are reported. The results of the structure–activity relationship study are discussed. Quinones such as Calothrixins A and B display a range of biological properties. As part of our ongoing studies to elucid...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2007, Vol.17 (1), p.82-85
Main Authors: Bernardo, Paul H., Chai, Christina L.L., Guen, Maurice Le, Smith, Geoffrey D., Waring, Paul
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
Humans
Indole Alkaloids - chemistry
Mice
Quinones - chemical synthesis
Quinones - chemistry
Quinones - pharmacology
SAR
Structure-Activity Relationship
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Summary:The biological activities of Calothrixin B and six related analogues against three cell lines are reported. The results of the structure–activity relationship study are discussed. Quinones such as Calothrixins A and B display a range of biological properties. As part of our ongoing studies to elucidate the mechanism of action of the Calothrixins, several related quinones were synthesized and tested for biological activity. The results of the structure–activity relationship (SAR) studies are reported here.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.09.090