Application of liquid chromatography-mass spectrometry technology for early detection of microalbuminuria in patients with kidney disease

Proteinuria is an early and sensitive marker of renal damage in many forms of chronic kidney disease, in diabetes mellitus, mild albuminurie occurs early in the course of renal damage, and this microalbuminuria, defined as urinary albumin excretion of 30-300 mg/day (-20-200 µg/min), is the best noni...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2006-11, Vol.52 (11), p.2155-2157
Main Authors: Babic, N, Larson, T S, Grebe, S K, Turner, S T, Kumar, R, Singh, R J
Format: Article
Language:English
Subjects:
Albuminuria - diagnosis
Amino Acid Sequence
Amino acids
Animals
Cattle
Chromatography
Chromatography, Liquid
Diabetes
Drug therapy
Humans
Immunoassay
Kidney diseases
Kidney Diseases - diagnosis
Kidneys
Liquid chromatography
Liquids
Mass Spectrometry
Molecular Sequence Data
Patients
Proteins
Reference Standards
Serum Albumin - analysis
Serum Albumin - standards
Serum Albumin, Bovine - analysis
Serum Albumin, Bovine - standards
Urine
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Summary:Proteinuria is an early and sensitive marker of renal damage in many forms of chronic kidney disease, in diabetes mellitus, mild albuminurie occurs early in the course of renal damage, and this microalbuminuria, defined as urinary albumin excretion of 30-300 mg/day (-20-200 µg/min), is the best noninvasive predictor of subsequent clinical diabetic nephropathy.
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2006.072892