Prognostic and predictive value of c-erbB2 overexpression in osteogenic sarcoma

Background: Osteogenic sarcoma (OS) is a highly malignant tumor of the bone. There are few reports in the literature regarding determination of c-erb B-2 (HER-2/neu) expression in cases of OS and also the results are quite variable. Aim: The present study was undertaken to correlate the expression o...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cancer research and therapeutics 2006-01, Vol.2 (1), p.20-23
Main Author: Rakesh Kumar Vasishta, Gupta Nalini, Kakkar Nandita, Sharma SC
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bone Neoplasms - metabolism
Bone Neoplasms - mortality
Bone Neoplasms - pathology
Child
Female
Humans
Immunohistochemistry
Male
Medical research
Medicine, Experimental
Osteogenic sarcoma, c-erbB-2, Immunohistochemistry
Osteosarcoma - metabolism
Osteosarcoma - mortality
Osteosarcoma - pathology
Predictive Value of Tests
Prognosis
Receptor, ErbB-2 - biosynthesis
Retrospective Studies
Sarcoma
Survival Analysis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Osteogenic sarcoma (OS) is a highly malignant tumor of the bone. There are few reports in the literature regarding determination of c-erb B-2 (HER-2/neu) expression in cases of OS and also the results are quite variable. Aim: The present study was undertaken to correlate the expression of c-erbB2 with the survival of patients of OS. Settings and Design: A retrospective study of cases of OS, in which the expression of c-erbB-2 by immunohistochemistry (IHC) was studied and correlated with the survival rate of the patients. Materials and Methods: Out of a total of 49 cases, proper follow up data in the form of total and disease free survival was available in only 20 cases. IHC for c-erb-B2 was carried out in these 20 cases. Results: The staining pattern was as follows: no staining in 3 cases, 1 + in 5 cases, 2 + in 3 cases, 3 + in 3 cases and 4 + cytoplasmic positivity in 6 cases. Statistical analysis: Spearman rank correlation test was used to correlate the intensity of cytoplasmic staining of c-erbB-2 with survival rate of the patients, response to chemotherapy and metastasis. Conclusions: Previous studies have shown that c-erbB-2/ HER-2 is an independent prognostic factor in osteogenic sarcoma, but in the present study, its expression was not seen to be correlating with survival rate of the patients. Therefore, further studies are needed to reach a consensus regarding the reliability of c-erbB-2 as an independent prognostic factor in OS.
ISSN:0973-1482
1998-4138
DOI:10.4103/0973-1482.19770