Late gadolinium enhancement-cardiovascular magnetic resonance as a predictor of response to cardiac resynchronization therapy in patients with ischaemic cardiomyopathy

Aim To determine whether myocardial scarring, quantified using late gadolinium enhancement-cardiovascular magnetic resonance (LGE-CMR), predicts response to cardiac resynchronization therapy (CRT). Methods and results A total of 45 patients with ischaemic cardiomyopathy [age 67.1 ± 10.4 years (mean...

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Bibliographic Details
Published in:Europace (London, England) England), 2007-11, Vol.9 (11), p.1031-1037
Main Authors: Chalil, Shajil, Foley, Paul W.X., Muyhaldeen, Sarkaw A., Patel, Kiran C.R., Yousef, Zaheer R., Smith, Russell E.A., Frenneaux, Michael P., Leyva, Francisco
Format: Article
Language:English
Subjects:
Aged
Cardiac Pacing, Artificial - methods
Cicatrix - diagnostic imaging
Cicatrix - pathology
Echocardiography
Exercise Tolerance - physiology
Female
Gadolinium
Humans
Logistic Models
Magnetic Resonance Imaging - methods
Male
Middle Aged
Multivariate Analysis
Myocardial Ischemia - diagnostic imaging
Myocardial Ischemia - pathology
Myocardial Ischemia - therapy
Myocardium - pathology
Predictive Value of Tests
Quality of Life
Treatment Outcome
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Summary:Aim To determine whether myocardial scarring, quantified using late gadolinium enhancement-cardiovascular magnetic resonance (LGE-CMR), predicts response to cardiac resynchronization therapy (CRT). Methods and results A total of 45 patients with ischaemic cardiomyopathy [age 67.1 ± 10.4 years (mean ± SD)] underwent assessment of 6 min walking distance (6MWD) and quality of life (QoL) before and after CRT. Scar size (percentage of left ventricular mass), location, and transmurality were assessed prior to CRT using LGE-CMR. Responders (survived for 1year with no heart failure hospitalizations, and improvement by ≥1 NYHA classes or ≥25% 6MWD) had a higher left ventricular ejection fraction (P = 0.048), smaller scars (
ISSN:1099-5129
1532-2092
DOI:10.1093/europace/eum133