Respiratory syncytial virus infections in hospitalized infants: Association between viral load, virus subgroup, and disease severity

The relationships between host factors, virus strain, viral load, and illness severity in respiratory syncytial virus (RSV)-induced bronchiolitis are poorly defined. These relationships were evaluated prospectively in 81 previously healthy infants hospitalized with RSV bronchiolitis. Disease severit...

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Bibliographic Details
Published in:Journal of medical virology 2007-12, Vol.79 (12), p.1951-1958
Main Authors: Fodha, Imène, Vabret, Astrid, Ghedira, Leila, Seboui, Hassen, Chouchane, Slaheddine, Dewar, John, Gueddiche, Neji, Trabelsi, Abdelhalim, Boujaafar, Noureddine, Freymuth, François
Format: Article
Language:English
Subjects:
Biological and medical sciences
disease severity
Fundamental and applied biological sciences. Psychology
Human viral diseases
Humans
Infant
Infant, Newborn
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - diagnosis
Respiratory Syncytial Virus Infections - virology
Respiratory Syncytial Virus, Human - classification
risk factors
RSV subgroups
Viral diseases
Viral Load
Virology
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Summary:The relationships between host factors, virus strain, viral load, and illness severity in respiratory syncytial virus (RSV)-induced bronchiolitis are poorly defined. These relationships were evaluated prospectively in 81 previously healthy infants hospitalized with RSV bronchiolitis. Disease severity was determined by the respiratory rate, the duration of hospitalization, and whether patients during their hospitalization required pediatric intensive care unit admission or mechanical ventilation. RSV typing into subgroup A and B was obtained by RT-PCR-hybridization assay. The nasopharyngeal RSV viral loads were measured by real-time quantitative RT-PCR. Disease severity correlated significantly with the presence of risk factor (estimated gestational age < 37 weeks and/or birth weight < 2,500 g) and with chronologic age
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.21026