Fibrinogen, plasma viscosity and blood viscosity in obesity. Relationship with insulin resistance

Plasma viscosity (PV) and blood viscosity (BV) have been scarcely evaluated in morbid obese patients with no other concomitant cardiovascular risk factors. Contradictory results have been published regarding the influence of insulin resistance on these rheological parameters in obesity. In 67 severe...

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Bibliographic Details
Published in:Clinical hemorheology and microcirculation 2007, Vol.37 (4), p.309-318
Main Authors: Solá, E, Vayá, A, Simó, M, Hernández-Mijares, A, Morillas, C, España, F, Estellés, A, Corella, D
Format: Article
Language:English
Subjects:
Adult
Blood Viscosity - physiology
Body Mass Index
Caloric Restriction
Case-Control Studies
Female
Fibrinogen - metabolism
Humans
Insulin Resistance
Male
Middle Aged
Obesity, Morbid - blood
Obesity, Morbid - diet therapy
Obesity, Morbid - metabolism
Weight Loss - physiology
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Summary:Plasma viscosity (PV) and blood viscosity (BV) have been scarcely evaluated in morbid obese patients with no other concomitant cardiovascular risk factors. Contradictory results have been published regarding the influence of insulin resistance on these rheological parameters in obesity. In 67 severe or morbid obese patients without other cardiovascular risk factors (51 women and 11 men, aged 34+/-11 years), fibrinogen, PV and BV at native (nBV) and corrected 45% hematocrit (cBV) have been determined, and insulin resistance has been calculated with homeostasis model assessment (HOMA) index, in basal conditions and after a three month diet period. The same determinations were performed in 67 healthy volunteers (45 women, 22 men, aged 32+/-10 years) at baseline and three months later. When cases and controls were compared, obese patients showed higher fibrinogen levels (P
ISSN:1386-0291