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Diversity and Antibiotic Resistance among Nonvaccine Serotypes of Streptococcus pneumoniae Carriage Isolates in the Post-Heptavalent Conjugate Vaccine Era

Background. In response to the selective pressure of pneumococcal conjugate vaccine, increased asymptomatic carriage of antibiotic-nonsusceptible nonvaccine serotypes (NVTs) has been observed. Possible mechanisms include de novo acquisition of resistance, serotype switching, introduction of new clon...

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Bibliographic Details
Published in:The Journal of infectious diseases 2007-02, Vol.195 (3), p.347-352
Main Authors: Hanage, William P., Huang, Susan S., Lipsitch, Marc, Bishop, Cynthia J., Godoy, Daniel, Pelton, Stephen I., Goldstein, Richard, Huot, Heather, Finkelstein, Jonathan A.
Format: Article
Language:English
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Summary:Background. In response to the selective pressure of pneumococcal conjugate vaccine, increased asymptomatic carriage of antibiotic-nonsusceptible nonvaccine serotypes (NVTs) has been observed. Possible mechanisms include de novo acquisition of resistance, serotype switching, introduction of new clones, and expansion of existing clones. Methods. To investigate the process of increased antibiotic nonsusceptibility among replacing serotypes, we applied multilocus sequence typing to samples of 126 and 222 pneumococci collected in 2001 and 2004, respectively, from the nasopharynges of children
ISSN:0022-1899
1537-6613
DOI:10.1086/510249