Plasmapheresis for hemolytic crisis and impending acute liver failure in Wilson disease

Wilsonian crisis is fatal unless copper removal is initiated early and liver transplantation is performed for patients that fulfill criteria for a poor outcome. We report a patient presenting with severe hemolysis and impending acute liver failure that made a rapid recovery with prompt initiation of...

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Bibliographic Details
Published in:Journal of clinical apheresis 2007-01, Vol.22 (5), p.295-298
Main Authors: Asfaha, Samuel, Almansori, Mohammed, Qarni, Uwais, Gutfreund, Klaus S.
Format: Article
Language:English
Subjects:
acute liver failure
Adolescent
Anemia, Hemolytic - etiology
Anemia, Hemolytic - therapy
Chelation Therapy
continuous veno‐venous hemodialysis
Female
Hemolysis
hemolytic anemia
Hepatolenticular Degeneration - complications
Humans
Liver Failure, Acute - etiology
Liver Failure, Acute - therapy
molecular adsorbents and recirculating system
Plasmapheresis
Treatment Outcome
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Summary:Wilsonian crisis is fatal unless copper removal is initiated early and liver transplantation is performed for patients that fulfill criteria for a poor outcome. We report a patient presenting with severe hemolysis and impending acute liver failure that made a rapid recovery with prompt initiation of plasmapheresis and chelation therapy. Rapid copper removal by plasmapheresis alleviated hemolysis and liver injury. A review of the literature was performed examining the use of plasmapheresis and albumin dialysis with continuous veno‐venous hemodialysis or molecular adsorbents and recirculating system. J. Clin. Apheresis, 2007. © 2007 Wiley‐Liss, Inc.
ISSN:0733-2459
1098-1101
DOI:10.1002/jca.20140