Biomaterial osseointegration enhancement with biophysical stimulation

Despite the ongoing improvement in implant characteristics, bone intrinsic potential for regeneration may be stimulated with adjuvant therapies to standard surgical procedures, as it is important to achieve the best possible implant osseointegration into the adjacent bone and to ensure therefore lon...

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Bibliographic Details
Published in:Journal of musculoskeletal & neuronal interactions 2007-07, Vol.7 (3), p.253-265
Main Authors: Dimitriou, R, Babis, G C
Format: Article
Language:English
Subjects:
Absorbable Implants
Animals
Bone and Bones - physiology
Bone and Bones - radiation effects
Bone and Bones - surgery
Electric Stimulation Therapy - methods
Electromagnetic Fields
Fracture Healing - physiology
Fracture Healing - radiation effects
Fractures, Bone - therapy
Humans
Internal Fixators
Osseointegration - physiology
Ultrasonic Therapy - methods
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Summary:Despite the ongoing improvement in implant characteristics, bone intrinsic potential for regeneration may be stimulated with adjuvant therapies to standard surgical procedures, as it is important to achieve the best possible implant osseointegration into the adjacent bone and to ensure therefore long-term implant stability. For this purpose various pharmacological, biological or biophysical modalities have been developed, such as bone grafting materials, pharmacological agents, growth factors and bone morphogenetic proteins. Biophysical stimulation of osseointegration includes two non-invasive and safe methods that have been initially developed to enhance fracture healing: pulsed electromagnetic fields (PEMFs) and lowintensity ultrasounds (LIPUS), for which most studies confirm their beneficial effects. The present paper is an overview of bone-implant osseointegration and the current trends on its enhancement, focusing mainly on the two methods of biophysical stimulation.
ISSN:1108-7161