Mechanisms regulating epithelial stratification

The epidermis is a stratified epithelium that functions as a barrier protecting the organism from dehydration, mechanical trauma, and microbial insults. This barrier function is established during embryogenesis through a complex and tightly controlled stratification program. Whereas the morphologica...

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Bibliographic Details
Published in:Annual review of cell and developmental biology 2007-01, Vol.23 (1), p.93-113
Main Authors: Koster, Maranke I, Roop, Dennis R
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Epidermis - cytology
Epidermis - embryology
Humans
Mice
Skin - cytology
Skin - embryology
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Summary:The epidermis is a stratified epithelium that functions as a barrier protecting the organism from dehydration, mechanical trauma, and microbial insults. This barrier function is established during embryogenesis through a complex and tightly controlled stratification program. Whereas the morphological changes that occur during epidermal development have been extensively studied, the molecular mechanisms that govern this process remain poorly understood. In this review we summarize the current advances that have been made in understanding the molecular mechanisms that regulate epidermal morphogenesis.
ISSN:1081-0706
1530-8995
DOI:10.1146/annurev.cellbio.23.090506.123357