Regulatory Role of Lymphoid Chemokine CCL19 and CCL21 in the Control of Allergic Rhinitis

The lymphoid chemokines CCL19 and CCL21 are known to be crucial both for lymphoid cell trafficking and for the structural organization of lymphoid tissues such as nasopharynx-associated lymphoid tissue (NALT). However, their role in allergic responses remains unclear, and so our current study aims t...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of immunology (1950) 2007-11, Vol.179 (9), p.5897-5906
Main Authors: Takamura, Kaoru, Fukuyama, Satoshi, Nagatake, Takahiro, Kim, Dong-Young, Kawamura, Aya, Kawauchi, Hideyuki, Kiyono, Hiroshi
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Chemokine CCL19 - genetics
Chemokine CCL19 - metabolism
Chemokine CCL21 - genetics
Chemokine CCL21 - metabolism
Dendritic Cells - cytology
DNA - genetics
Hypersensitivity - metabolism
Hypersensitivity - pathology
Immunoglobulin E - biosynthesis
Immunoglobulin E - immunology
Lymphocyte Count
Lymphoid Tissue - metabolism
Mice
Mice, Inbred BALB C
Rhinitis - metabolism
Rhinitis - pathology
T-Lymphocytes, Regulatory - cytology
Th1 Cells - metabolism
Th2 Cells - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The lymphoid chemokines CCL19 and CCL21 are known to be crucial both for lymphoid cell trafficking and for the structural organization of lymphoid tissues such as nasopharynx-associated lymphoid tissue (NALT). However, their role in allergic responses remains unclear, and so our current study aims to shed light on the role of CCL19/CCL21 in the development of allergic rhinitis. After nasal challenge with OVA, OVA-sensitized plt (paucity of lymph node T cells) mice, which are deficient in CCL19/CCL21, showed more severe allergic symptoms than did identically treated wild-type mice. OVA-specific IgE production, eosinophil infiltration, and Th2 responses were enhanced in the upper airway of plt mice. Moreover, in plt mice, the number of CD4(+)CD25(+) regulatory T cells declined in the secondary lymphoid tissues, whereas the number of Th2-inducer-type CD8alpha(-)CD11b(+) myeloid dendritic cells (m-DCs) increased in cervical lymph nodes and NALT. Nasal administration of the plasmid-encoding DNA of CCL19 resulted in the reduction of m-DCs in the secondary lymphoid tissues and the suppression of allergic responses in plt mice. These results suggest that CCL19/CCL21 act as regulatory chemokines for the control of airway allergic disease and so may offer a new strategy for the control of allergic disease.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.179.9.5897