diagnostic tool for determining the quality of accuracy validation. Assessing the method for determination of nitrate in drinking water

Realistic internal validation of a method implies the performance validation experiments under intermediate precision conditions. The validation results can be organized in an X NrxNs (replicatesxruns) data matrix, analysis of which enables assessment of the accuracy of the method. By means of Monte...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2007-01, Vol.387 (2), p.619-625
Main Authors: Escuder-Gilabert, L, Bonet-Domingo, E, Medina-Hernández, M. J, Sagrado, S
Format: Article
Language:English
Subjects:
Accuracy validation
Bias
Intermediate precision
Methods
Monte Carlo Method
Monte Carlo simulation
Nitrites - analysis
Reproducibility of Results
Uncertainty estimation
Water - analysis
Water Supply - standards
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Summary:Realistic internal validation of a method implies the performance validation experiments under intermediate precision conditions. The validation results can be organized in an X NrxNs (replicatesxruns) data matrix, analysis of which enables assessment of the accuracy of the method. By means of Monte Carlo simulation, uncertainty in the estimates of bias and precision can be assessed. A bivariate plot is presented for assessing whether the uncertainty intervals for the bias (E ± U(E)) and intermediate precision (RSDi ± U(RSDi) are included in prefixed limits (requirements for the method). As a case study, a method for determining the concentration of nitrate in drinking water at the official level set by 98/83/EC Directive is assessed by use of the proposed plot.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-006-0941-0