Understanding the physiology and adaptation of staphylococci: A post-genomic approach

Abstract Staphylococcus aureus as well as coagulase-negative staphylococci are medically highly important pathogens characterized by an increasing resistance rate toward many antibiotics. Although normally being skin and mucosa commensals, some staphylococcal species and strains have the capacity to...

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Published in:International journal of medical microbiology 2007-11, Vol.297 (7), p.483-501
Main Authors: Becker, Karsten, Bierbaum, Gabriele, von Eiff, Christof, Engelmann, Susanne, Götz, Friedrich, Hacker, Jörg, Hecker, Michael, Peters, Georg, Rosenstein, Ralf, Ziebuhr, Wilma
Format: Article
Language:English
Subjects:
Coagulase-negative staphylococci
Gene Expression Profiling
Genetic adaptation
Genome structure
Humans
Infectious Disease
Medical Education
Physiology
Proteome
Proteomics
Staphylococcal Infections - microbiology
Staphylococcal Infections - transmission
Staphylococcus - genetics
Staphylococcus - pathogenicity
Staphylococcus - physiology
Staphylococcus aureus
Staphylococcus aureus - pathogenicity
Transcriptome
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Summary:Abstract Staphylococcus aureus as well as coagulase-negative staphylococci are medically highly important pathogens characterized by an increasing resistance rate toward many antibiotics. Although normally being skin and mucosa commensals, some staphylococcal species and strains have the capacity to cause a wide range of infectious diseases. Many of these infections affect immunocompromised patients in hospitals. However, community-acquired staphylococcal infections due to resistant strains are also currently on the rise. In the light of this development, there is an urgent need for novel anti-staphylococcal therapeutic and prevention strategies for which a better understanding of the physiology of these bacteria is an essential prerequisite. Within the past years, staphylococci have been in the focus of genomic research, resulting in the determination and publication of a range of full-genome sequences of different staphylococcal species and strains which provided the basis for the design and application of DNA microarrays and other genomic tools. Here we summarize the results of the project group ‘Staphylococci’ within the research network ‘Pathogenomics’ giving new insights into the genome structure, molecular epidemiology, physiology, and genetic adaptation of both S. aureus and coagulase-negative staphylococci.
ISSN:1438-4221
1618-0607
DOI:10.1016/j.ijmm.2007.04.004