Drug-Eluting Stent Safety

Drug-eluting stents (DESs) held the promise of mitigating, if not abolishing, in-stent restenosis. This led to early adoption and high penetration of DES use in percutaneous coronary intervention (PCI). Outcomes have not demonstrated an improvement in the hard end points of death and myocardial infa...

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Bibliographic Details
Published in:The American journal of cardiology 2007-10, Vol.100 (8), p.S10-S17
Main Authors: Slottow, Tina L. Pinto, MD, Waksman, Ron, MD
Format: Article
Language:English
Subjects:
Angioplasty
Angioplasty, Balloon, Coronary - adverse effects
Cardiology
Cardiovascular
Coronary Disease - therapy
Coronary Restenosis - etiology
Coronary Restenosis - prevention & control
Coronary Thrombosis - etiology
Coronary Thrombosis - physiopathology
Drug-Eluting Stents - adverse effects
Drug-Eluting Stents - trends
Heart attacks
Humans
Safety
Stents
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Description
Summary:Drug-eluting stents (DESs) held the promise of mitigating, if not abolishing, in-stent restenosis. This led to early adoption and high penetration of DES use in percutaneous coronary intervention (PCI). Outcomes have not demonstrated an improvement in the hard end points of death and myocardial infarction with these devices, but repeat procedures for in-stent restenosis have decreased. The problem of stent thrombosis, a major obstacle that arose early in coronary stent development, has raised new contemporary concerns about the safety of DESs. The risk for stent thrombosis after bare metal stent placement appears to diminish with time, while very late stent thrombosis (>1 year after index PCI) occurs in small but measurable numbers after DES placement at a rate that continues to increase. Late-acquired incomplete stent apposition and abnormal endothelial function have also been reported. Restenosis, although significantly lessened, does occur after DES PCI. This report reviews DES safety issues that have been described.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2007.08.017