Alternative roles for metal ions in enzyme catalysis and the implications for ribozyme chemistry

It is evident that RNAs are always associated with metal ions, but there have been several studies indicating that ribozymes such as the hairpin, hammerhead, and certain in-vitro-selected ribozymes or DNAzymes can promote catalysis also in the absence of Mg2+ or related divalent ions. The ways that...

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Bibliographic Details
Published in:Chemical reviews 2007-01, Vol.107 (1), p.97-113
Main Authors: Sigel, Roland K O, Pyle, Anna Marie
Format: Article
Language:English
Subjects:
Binding Sites
Biochemistry
Catalysis
Cations - chemistry
Deoxyribonucleic acid
DNA
Enzymes
Enzymes - chemistry
Metals
Metals - chemistry
Models, Molecular
Molecular Structure
Ribonucleic acid
RNA
RNA, Catalytic - chemistry
Solvents - chemistry
Static Electricity
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Summary:It is evident that RNAs are always associated with metal ions, but there have been several studies indicating that ribozymes such as the hairpin, hammerhead, and certain in-vitro-selected ribozymes or DNAzymes can promote catalysis also in the absence of Mg2+ or related divalent ions. The ways that model systems and protein enzymes utilize metal ions for catalysis are considered and how these observations work in ribozyme enzymology are related.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr0502605