Photogenerated glycan arrays identify immunogenic sugar moieties of Bacillus anthracis exosporium

Using photogenerated glycan arrays, we characterized a large panel of synthetic carbohydrates for their antigenic reactivities with pathogen‐specific antibodies. We discovered that rabbit IgG antibodies elicited by Bacillus anthracis spores specifically recognize a tetrasaccharide chain that decorat...

Full description

Saved in:
Bibliographic Details
Published in:Proteomics (Weinheim) 2007-01, Vol.7 (2), p.180-184
Main Authors: Wang, Denong, Carroll, Gregory T., Turro, Nicholas J., Koberstein, Jeffrey T., Kováč, Pavol, Saksena, Rina, Adamo, Roberto, Herzenberg, Leonore A., Herzenberg, Leonard A., Steinman, Lawrence
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Animals
Antibody
Antigens, Bacterial - chemistry
Antigens, Bacterial - immunology
Bacillus anthracis - chemistry
Bacillus anthracis - immunology
Bacteria
Biological and medical sciences
Biomarker
Carbohydrates
Fundamental and applied biological sciences. Psychology
Light
Microarray Analysis
Miscellaneous
Polysaccharides - chemistry
Polysaccharides - immunology
Proteins
Rabbits
Spores, Bacterial - chemistry
Spores, Bacterial - immunology
Sugar chips
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Using photogenerated glycan arrays, we characterized a large panel of synthetic carbohydrates for their antigenic reactivities with pathogen‐specific antibodies. We discovered that rabbit IgG antibodies elicited by Bacillus anthracis spores specifically recognize a tetrasaccharide chain that decorates the outermost surfaces of the B. anthracis exosporium. Since this sugar moiety is highly specific for the spores of B. anthracis, it appears to be a key biomarker for detection of B. anthracis spores and development of novel vaccines that target anthrax spores.
ISSN:1615-9853
1615-9861
DOI:10.1002/pmic.200600478