FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy

F-box proteins are key components of SCF (Skp1–Cullin1–F-box protein) complexes, which exert E3 ubiquitin ligase activity and participate in cell cycle and signal transduction. F-box proteins interact with Skp1 through the F-box domain and with proteins to be ubiquitinated through other interaction...

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Bibliographic Details
Published in:Gene 2007-12, Vol.404 (1), p.53-60
Main Authors: Ye, Jianwei, Zhang, Yong, Xu, Jialin, Zhang, Qiang, Zhu, Dahai
Format: Article
Language:English
Subjects:
Animals
Blotting, Northern
Blotting, Western
Cytoplasm - chemistry
Cytoplasm - metabolism
F-box proteins
F-Box Proteins - analysis
F-Box Proteins - chemistry
F-Box Proteins - genetics
FBXO40
Female
Gene Expression
Humans
Mice
Mice, Inbred BALB C
Muscle atrophy
Muscle Denervation
Muscle development
Muscle Development - genetics
Muscle Proteins - analysis
Muscle Proteins - chemistry
Muscle Proteins - genetics
Muscle, Skeletal - growth & development
Muscle, Skeletal - innervation
Muscular Atrophy - genetics
Muscular Dystrophies, Limb-Girdle - genetics
Polymerase Chain Reaction
Rats
Rats, Sprague-Dawley
RNA, Messenger - analysis
Up-Regulation
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Summary:F-box proteins are key components of SCF (Skp1–Cullin1–F-box protein) complexes, which exert E3 ubiquitin ligase activity and participate in cell cycle and signal transduction. F-box proteins interact with Skp1 through the F-box domain and with proteins to be ubiquitinated through other interaction domains. We have characterized a novel muscle-specific F-box protein, FBXO40, the expression of which decreases in the dystrophic muscle of Limb-girdle muscular dystrophy (LGMD) patient. During the development of skeletal muscle, FBXO40 can only be detected at postnatal stage from about 2 weeks after birth. By overexpressing in C2C12 cells, FBXO40 localized in cytoplasm. Most importantly, the expression of FBXO40 can be upregulated in skeletal muscle from denervation- but not starvation-related muscle atrophy. All our data suggest that FBXO40 may function as a regulator involved in the postnatal myogenesis.
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2007.08.020