Involuting solitary cutaneous infantile myofibroma and thrombocytopaenia: a previously unreported clinical association

Summary Solitary and multicentric myofibromas are rare fibrous tumours with marked predilection for infants and young children. Presentation is mainly before the age of 2 and lesions are often congenital. Behaviour is usually benign, but mortality has been described in lesions with visceral involvem...

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Bibliographic Details
Published in:Journal of plastic, reconstructive & aesthetic surgery reconstructive & aesthetic surgery, 2007-01, Vol.60 (11), p.1260-1262
Main Authors: Leon-Villapalos, J, Wolfe, K, Calonje, E, Kangesu, L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Dermatology
Diseases in Twins - diagnosis
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Haemangioma
Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue
Humans
Infant
Infantile myofibroma
Kaposiform haemangioendothelioma
Kasabach–Merritt syndrome
Male
Medical sciences
Myofibroma - diagnosis
Neoplasm Regression, Spontaneous
Plastic Surgery
Skin Neoplasms - diagnosis
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Thrombocytopaenia
Thrombocytopenia - diagnosis
Treatment Outcome
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Summary:Summary Solitary and multicentric myofibromas are rare fibrous tumours with marked predilection for infants and young children. Presentation is mainly before the age of 2 and lesions are often congenital. Behaviour is usually benign, but mortality has been described in lesions with visceral involvement. We report a unique case of congenital solitary cutaneous infantile myofibroma in a neonate associated with self-limiting thrombocytopaenia. It is important to distinguish accurately these lesions from benign vascular tumours like haemangiomas, locally aggressive vascular tumours like Kaposiform haemangioendotheliomas, which are often associated with Kasabach–Merritt phenomenon and also with malignant soft tissue tumours of infancy.
ISSN:1748-6815
1878-0539
DOI:10.1016/j.bjps.2006.01.019