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Microwave-Assisted Solid-Phase Peptide Synthesis Utilizing N-Fmoc-Protected (α-aminoacyl)benzotriazoles

A novel microwave‐assisted solid‐phase peptide synthesis utilizing N‐Fmoc‐protected(α‐aminoacyl)benzotriazoles was applied in the preparation of tri‐, tetra‐, penta‐, hexa‐, and heptapeptides in 71% average crude yield.

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Published in:Chemical biology & drug design 2007-11, Vol.70 (5), p.465-468
Main Authors: Katritzky, Alan R., Khashab, Niveen M., Yoshioka, Megumi, Haase, Danniebelle N., Wilson, Krista R., Johnson, Jodie V., Chung, Alfred, Haskell-Luevano, Carrie
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Language:English
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cited_by cdi_FETCH-LOGICAL-c4364-b2d52951ab0c15035b6dcb692e1f38cb119b5290d46ef1ccb7809651071428e83
cites cdi_FETCH-LOGICAL-c4364-b2d52951ab0c15035b6dcb692e1f38cb119b5290d46ef1ccb7809651071428e83
container_end_page 468
container_issue 5
container_start_page 465
container_title Chemical biology & drug design
container_volume 70
creator Katritzky, Alan R.
Khashab, Niveen M.
Yoshioka, Megumi
Haase, Danniebelle N.
Wilson, Krista R.
Johnson, Jodie V.
Chung, Alfred
Haskell-Luevano, Carrie
description A novel microwave‐assisted solid‐phase peptide synthesis utilizing N‐Fmoc‐protected(α‐aminoacyl)benzotriazoles was applied in the preparation of tri‐, tetra‐, penta‐, hexa‐, and heptapeptides in 71% average crude yield.
doi_str_mv 10.1111/j.1747-0285.2007.00584.x
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source Wiley-Blackwell Read & Publish Collection
subjects Benzene Derivatives - chemical synthesis
Benzene Derivatives - chemistry
microwave irradiation
Microwaves
Models, Molecular
Molecular Conformation
N-Fmoc-protected(α-aminoacyl)benzotriazole
peptides
Peptides - chemical synthesis
Peptides - chemistry
Rink amide resin
solid-phase peptide synthesis
Triazoles - chemical synthesis
Triazoles - chemistry
title Microwave-Assisted Solid-Phase Peptide Synthesis Utilizing N-Fmoc-Protected (α-aminoacyl)benzotriazoles
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