A human monoclonal antibody cocktail as a novel component of rabies postexposure prophylaxis

The currently recommended treatment for individuals exposed to rabies virus is the combined administration of rabies vaccine and rabies immune globulin (RIG). This review sets out the criteria used to guide development of a cocktail of human monoclonal antibodies as a replacement for RIG. Using this...

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Bibliographic Details
Published in:Annual review of medicine 2007-01, Vol.58 (1), p.359-368
Main Authors: de Kruif, John, Bakker, Alexander B H, Marissen, Wilfred E, Kramer, R Arjen, Throsby, Mark, Rupprecht, Charles E, Goudsmit, Jaap
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal - therapeutic use
Humans
Immune system
Immunoglobulin G - immunology
Immunoglobulins
Immunoglobulins - therapeutic use
Immunologic Factors - therapeutic use
Immunology
Rabies
Rabies - prevention & control
Rabies virus
Rabies virus - immunology
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Summary:The currently recommended treatment for individuals exposed to rabies virus is the combined administration of rabies vaccine and rabies immune globulin (RIG). This review sets out the criteria used to guide development of a cocktail of human monoclonal antibodies as a replacement for RIG. Using this process as a model, the general requirements for development of safe and efficacious monoclonal antibody alternatives to currently used polyclonal serum products are discussed.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev.med.58.061705.145053