Novel nucleotide triphosphates as potent P2Y2 agonists

The synthesis and P2Y2 activities of a novel series of nucleoside triphosphates are described. Many of these compounds were potent agonists of the P2Y2 receptor.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2007-01, Vol.17 (2), p.562-565
Main Authors: BROOKINGS, Daniel, DAVENPORT, Richard J, DAVIS, Jeremy, GALVIN, Frances C. A, LLOYD, Steve, MACK, Stephen R, OWENS, Ray, SABIN, Verity, WYNN, Joanne
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Line, Tumor
DNA, Complementary - biosynthesis
DNA, Complementary - genetics
Humans
Indicators and Reagents
Magnetic Resonance Spectroscopy
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Nucleotides - chemical synthesis
Nucleotides - pharmacology
Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
Pharmacology. Drug treatments
Purinergic P2 Receptor Agonists
Receptors, Purinergic P2Y2
Reverse Transcriptase Polymerase Chain Reaction
Structure-Activity Relationship
Uridine Triphosphate - pharmacology
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Description
Summary:The synthesis and P2Y2 activities of a novel series of nucleoside triphosphates are described. Many of these compounds were potent agonists of the P2Y2 receptor.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.09.017