Increase of imipenem resistance among Pseudomonas aeruginosa isolates from a Polish paediatric hospital (1993–2002)

Abstract Analysis of the in vitro activity of imipenem and 13 other antibiotics against 2485 Pseudomonas aeruginosa isolates obtained from clinical specimens from children hospitalized during 1993–2002 was performed. In 2002, the percentage of P. aeruginosa isolates susceptible to all tested antibio...

Full description

Saved in:
Bibliographic Details
Published in:International journal of antimicrobial agents 2007-02, Vol.29 (2), p.153-158
Main Authors: Patzer, Jan A, Dzierżanowska, Danuta
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Child
Drug Resistance, Bacterial
Humans
Imipenem
Imipenem - pharmacology
Infectious Disease
Medical sciences
MIC
Microbial Sensitivity Tests
PFGE
Pharmacology. Drug treatments
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - isolation & purification
Serotypes
Susceptibility
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Analysis of the in vitro activity of imipenem and 13 other antibiotics against 2485 Pseudomonas aeruginosa isolates obtained from clinical specimens from children hospitalized during 1993–2002 was performed. In 2002, the percentage of P. aeruginosa isolates susceptible to all tested antibiotics, with the exception of imipenem, increased or remained on nearly the same level as in 1993. An increase of resistance to imipenem from 4.3% to 18.3% was observed. The MIC90 value of imipenem increased from 2 mg/L to 16 mg/L. Simultaneously, a four-fold increase of the usage of carbapenems imipenem and meropenem in the hospital was noted. In 2000–2001, a high incidence of imipenem-resistant strains was observed. The imipenem-resistant P. aeruginosa strains of serotype O6 from the general surgery ward and serotype O11 from the intensive care unit were shown to be clonally related by the pulsed-field gel electrophoresis method.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2006.08.044