Predisposition to infection in patients with pemphigus. Retrospective study of 141 cases

The relation between pemphigus and infection is complex. The aim of this work was to determine the frequency and impact of infection as well as the factors associated with it among our patients with pemphigus. This retrospective case series examined records of patients with pemphigus admitted to the...

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Published in:La Presse médicale (1983) 2007-11, Vol.36 (11 Pt 1), p.1563-1569
Main Authors: Belgnaoui, Fatima Zahra, Senouci, Karima, Chraibi, Hanane, Aoussar, Abdelaziz, Mansouri, Fatima, Benzekri, Laila, Ourhroui, Mohamed Ait, Abouqal, Redouane, Heid, Ernest, Hassam, Badredine
Format: Article
Language:fre
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Causality
Female
Humans
Infection - epidemiology
Infection - etiology
Male
Middle Aged
Pemphigus - complications
Retrospective Studies
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Summary:The relation between pemphigus and infection is complex. The aim of this work was to determine the frequency and impact of infection as well as the factors associated with it among our patients with pemphigus. This retrospective case series examined records of patients with pemphigus admitted to the dermatology unit of Ibn Sina University Hospital of Rabat between 1989 and 2004. We compared the patients with and without infections as well as the patients with and without severe bacterial infections according to patient profile and outcome. The principal outcome measure was death and the secondary measure, duration of hospitalization. Of the 141 patients with pemphigus included in our study, 68% developed an infection. Infections were bacterial in 52% of cases, fungal in 50%, herpetic in 19% and parasitic in 1.5%. They were associated with diabetes mellitus and immunosuppressive drugs. Severe bacterial infection was frequent in patients with diabetes and rare in those treated with corticosteroids or with pemphigus foliaceous. Death occurred significantly more often among infected subjects (p=0.01), especially those with severe bacterial infections (p
ISSN:0755-4982