Afterdischarges during cortical stimulation at different frequencies and intensities

Summary Purpose The occurrence of unwanted afterdischarges (ADs) impedes cortical stimulation for mapping purposes. We investigated the safety of several stimulation paradigms. Methods We compared the incidence of ADs and behavioral responses of two stimulation frequencies (50 and 100 Hz), at two in...

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Bibliographic Details
Published in:Epilepsy research 2007-10, Vol.77 (1), p.65-69
Main Authors: Motamedi, Gholam K, Okunola, Oladotun, Kalhorn, Christopher G, Mostofi, Navid, Mizuno-Matsumoto, Yuko, Cho, Yong-won, Meador, Kimford J
Format: Article
Language:English
Subjects:
Afterdischarges
Behavior
Biological and medical sciences
Brain Mapping
Cerebral Cortex - physiology
Cortical stimulation
Drug toxicity and drugs side effects treatment
Electric Stimulation - adverse effects
Electrodes, Implanted
Electroencephalography
Epilepsy
Epilepsy, Temporal Lobe - diagnosis
Epilepsy, Temporal Lobe - physiopathology
Epilepsy, Temporal Lobe - psychology
Frequency
Humans
Male
Malformations of the nervous system
Medical sciences
Middle Aged
Neurology
Pharmacology. Drug treatments
Pulse width
Toxicity: nervous system and muscle
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Summary:Summary Purpose The occurrence of unwanted afterdischarges (ADs) impedes cortical stimulation for mapping purposes. We investigated the safety of several stimulation paradigms. Methods We compared the incidence of ADs and behavioral responses of two stimulation frequencies (50 and 100 Hz), at two intensities (1 and 0.2 ms pulse widths). Results Stimulation with 100 Hz was more likely to cause ADs than 50 Hz, and stimulation using 1 ms pulse width was more likely to cause ADs than 0.2 ms. Conclusions Stimulation using 50 Hz frequency with a pulse width of 0.2 ms might be safer during cortical mapping.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2007.08.001