Functional response of hepatocytes transplanted into gunn rats stimulated with thyroid hormone

In the attempt to translate laboratory studies into clinical practice, the small number of cells that can be transplanted is currently a problem to be solved. The aim of this work is to study the functional response of intrasplenically transplanted syngeneic rat adult and fetal hepatocytes to a prol...

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Published in:Digestive diseases and sciences 2007, Vol.52 (1), p.210-216
Main Authors: CUBERO, Francisco J, MAGANTO, Paloma, MULA, Nieves, ORTIZ, Agustin, BARRUTIA, Maria G, CODESAL, Francisco J, ARAHUETES, Rosa M
Format: Article
Language:English
Subjects:
Animals
Bile - chemistry
Bilirubin - blood
Biological and medical sciences
Feeding. Feeding behavior
Fetal Tissue Transplantation
Fundamental and applied biological sciences. Psychology
Glucuronosyltransferase - metabolism
Hepatocytes - transplantation
Immunohistochemistry
Liver - embryology
Rats
Rats, Gunn
Spleen - metabolism
Thyroid gland
Thyroid Hormones - pharmacology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:In the attempt to translate laboratory studies into clinical practice, the small number of cells that can be transplanted is currently a problem to be solved. The aim of this work is to study the functional response of intrasplenically transplanted syngeneic rat adult and fetal hepatocytes to a proliferative stimulus, 3,5,3'-triiodothyronine. Total serum bilirubin significantly decreased from 7 to 90 days after fetal hepatocyte transplantation and from 24 hr to 30 days after adult hepatocyte transplantation. Concomitant with these changes, bile conjugated bilirubin increased from 7 to 90 days after fetal and from 24 hr to 30 days after adult hepatocyte transplantation. In both cases, administration of thyroid hormone enhances this effect. We conclude that although adult and fetal hepatocytes correct the hyperbilirubinemia, fetal cells function longer than adult hepatocytes. Thyroid hormone is a powerful stimulator of function of hepatocytes since it improves both adult and fetal response.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-006-9614-2