Influence of pirfenidone on airway hyperresponsiveness and inflammation in a Brown-Norway rat model of asthma

Abstract Pirfenidone was administered to sensitized Brown Norway rats prior to a series of ovalbumin challenges. Airway hyperresponsiveness, inflammatory cell infiltration, mucin and collagen content, and the degree of epithelium and smooth muscle staining for TGF- β were examined in control, sensit...

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Bibliographic Details
Published in:Pulmonary pharmacology & therapeutics 2007-01, Vol.20 (6), p.660-668
Main Authors: Mansoor, Jim K, Decile, Kendra C, Giri, Shri N, Pinkerton, Kent E, Walby, William F, Bratt, Jennifer M, Grewal, Harinder, Margolin, Solomon B, Schelegle, Edward S
Format: Article
Language:English
Subjects:
Airway hyperresponsiveness
Animals
Anti-Inflammatory Agents - pharmacology
Asthma
Asthma - drug therapy
Bronchi - cytology
Bronchi - drug effects
Bronchi - pathology
Bronchial Hyperreactivity - drug therapy
Bronchial Provocation Tests
Collagen - metabolism
Disease Models, Animal
Inflammation - drug therapy
Lung - drug effects
Lung - pathology
Male
Medical Education
Mucins - metabolism
Muscle, Smooth - drug effects
Muscle, Smooth - pathology
Ovalbumin
Ovalbumin challenge
Pirfenidone
Pulmonary/Respiratory
Pyridones - pharmacology
Random Allocation
Rats
Rats, Inbred BN
Respiratory Mucosa - drug effects
Respiratory Mucosa - pathology
TGF- β
Transforming Growth Factor beta - metabolism
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Summary:Abstract Pirfenidone was administered to sensitized Brown Norway rats prior to a series of ovalbumin challenges. Airway hyperresponsiveness, inflammatory cell infiltration, mucin and collagen content, and the degree of epithelium and smooth muscle staining for TGF- β were examined in control, sensitized, and sensitized/challenged rats fed a normal diet or pirfenidone diet. Pirfenidone had no effect on airway hyperresponsiveness, but reduced distal bronchiolar cell infiltration and proximal and distal mucin content. Statistical analysis showed that the control group and sensitized/challenged pirfenidone diet group TGF- β staining intensity scores were not significantly different from isotype controls, but that the staining intensity scores for the sensitized/challenged normal diet group was significantly different from isotype controls. These results suggest that pirfenidone treatment is effective in reducing some of the components of acute inflammation induced by allergen challenge.
ISSN:1094-5539
1522-9629
DOI:10.1016/j.pupt.2006.07.005