Efficacy of therapeutic hypothermia after out-of-hospital cardiac arrest due to ventricular fibrillation

Summary Aim of the study We investigated implementation and efficacy of mild therapeutic hypothermia in the treatment of out-of-hospital cardiac arrest due to ventricular fibrillation. Materials and methods Two periods were compared, an historical one (36 patients) between 2000 and 2002 where therap...

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Bibliographic Details
Published in:Resuscitation 2007-11, Vol.75 (2), p.252-259
Main Authors: Belliard, Guillaume, Catez, Emmanuel, Charron, Cyril, Caille, Vincent, Aegerter, Philippe, Dubourg, Olivier, Jardin, François, Vieillard-Baron, Antoine
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Cardiac arrest
Cardiopulmonary Resuscitation - methods
Emergency
Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
Emergency Medical Services - methods
Female
Follow-Up Studies
France - epidemiology
Heart Arrest - etiology
Heart Arrest - mortality
Heart Arrest - therapy
Humans
Hypothermia
Hypothermia, Induced - methods
Implementation
Intensive care medicine
Male
Medical sciences
Middle Aged
Retrospective Studies
Survival Rate - trends
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Treatment Outcome
Ventricular fibrillation
Ventricular Fibrillation - complications
Ventricular Fibrillation - mortality
Ventricular Fibrillation - therapy
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Summary:Summary Aim of the study We investigated implementation and efficacy of mild therapeutic hypothermia in the treatment of out-of-hospital cardiac arrest due to ventricular fibrillation. Materials and methods Two periods were compared, an historical one (36 patients) between 2000 and 2002 where therapeutic hypothermia was never used, and a recent period (32 patients) between 2003 and 2005 where therapeutic hypothermia (32–34 °C) was implemented prospectively in our unit. Cooling was obtained by simply using wet cloths and ice packs. Survival in the two groups and factors associated with survival were analysed, together with the neurological prognosis in discharged patients. Results Survival was significantly higher in the hypothermia group (56% versus 36%), whereas no significant difference was observed in severity between the two periods. Only age, time from return to spontaneous circulation
ISSN:0300-9572
1873-1570
DOI:10.1016/j.resuscitation.2007.04.014