Relationship of serum brain-derived neurotrophic factor level with other markers of disease severity in patients with atopic dermatitis

Abstract Elevated serum levels of neurotrophins such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) have been reported in allergic and autoimmune diseases. The aim of this study was to assess serum levels of BDNF in patients with atopic dermatitis (AD) and to investigate t...

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Bibliographic Details
Published in:Clinical Immunology 2007-02, Vol.122 (2), p.181-186
Main Authors: Namura, Kenji, Hasegawa, Goji, Egawa, Masato, Matsumoto, Tadasu, Kobayashi, Rina, Yano, Tadashi, Katoh, Norito, Kishimoto, Saburo, Ohta, Mitsuhiro, Obayashi, Hiroshi, Ose, Hiroyuki, Fukui, Michiaki, Nakamura, Naoto, Yoshikawa, Toshikazu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allergic diseases
Allergy and Immunology
Atopic dermatitis
Biological and medical sciences
Biomarkers - blood
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
Dermatitis, Atopic - blood
Eosinophils
Eosinophils - metabolism
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunopathology
Male
Medical sciences
Nerve Growth Factor - blood
Severity of Illness Index
Skin allergic diseases. Stinging insect allergies
Th1/Th2 cells
Th2 Cells - metabolism
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Summary:Abstract Elevated serum levels of neurotrophins such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) have been reported in allergic and autoimmune diseases. The aim of this study was to assess serum levels of BDNF in patients with atopic dermatitis (AD) and to investigate the relationship of the BDNF level with other markers of disease severity. Serum BDNF concentration was significantly higher in patients with AD ( n = 62) compared to control subjects ( n = 20) ( P < 0.01). Stepwise multiple regression analysis showed a significant influence of the peripheral blood eosinophil counts ( F = 6.90) and the percentage of CD4+ IL-4+ (Th2) cells ( F = 6.61). Moreover, after remission of AD patients with conventionally treated AD patients ( n = 14), serum levels of BDNF, eosinophil counts and percentage of Th2 cells were decreased significantly. These results suggest that serum BDNF may be a useful marker of disease activity in AD and that both eosinophils and Th2 cells are major cellular sources of serum BDNF.
ISSN:1521-6616
1521-7035
1365-2567
DOI:10.1016/j.clim.2006.10.011