Analogues of 2-crotonyloxymethyl-(4 R,5 R,6 R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties

The syntheses of three novel analogues of the naturally occurring cytotoxic agent COTC are described and the results of bioassays of the target compounds against two lung cancer cell lines are presented.

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2007-01, Vol.17 (2), p.553-557
Main Authors: Arthurs, Claire L., Wind, Natasha S., Whitehead, Roger C., Stratford, Ian J.
Format: Article
Language:English
Subjects:
Anti-tumor
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Biological and medical sciences
Cell Line, Tumor
Cyclohexanones - chemical synthesis
Cyclohexanones - pharmacology
Drug Design
General aspects
Glutathione - metabolism
Glutathione transferase
Humans
Indicators and Reagents
Lung Neoplasms - drug therapy
Medical sciences
Natural product
Organo-fluorine
Pharmacology. Drug treatments
Synthetic analogue
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The syntheses of three novel analogues of the naturally occurring cytotoxic agent COTC are described and the results of bioassays of the target compounds against two lung cancer cell lines are presented.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.09.072