Histology of the porcine mandibular distraction wound

The purpose of this study was to document the progression and pattern of endosteal bone formation in a porcine mandibular distraction wound. Bone formation was assessed in a 0-day latency model ( n = 24 pigs) using distraction rates of 1, 2, or 4 mm/day to create a 12-mm gap. Macro-radiographs and s...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2005-06, Vol.34 (4), p.411-419
Main Authors: Zimmermann, C.E., Thurmüller, P., Troulis, M.J., Perrott, D.H., Rahn, B., Kaban, L.B.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Biological and medical sciences
Bone Regeneration
Dentistry
distraction osteogenesis
Female
Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics
histology
Linear Models
Mandible - diagnostic imaging
Mandible - surgery
mandibular distraction
Maxillofacial surgery. Dental surgery. Orthodontics
Medical sciences
Models, Animal
Osteoblasts - physiology
Osteogenesis, Distraction
Otorhinolaryngology. Stomatology
Periosteum - physiology
Radiography
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Swine
Swine, Miniature
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Summary:The purpose of this study was to document the progression and pattern of endosteal bone formation in a porcine mandibular distraction wound. Bone formation was assessed in a 0-day latency model ( n = 24 pigs) using distraction rates of 1, 2, or 4 mm/day to create a 12-mm gap. Macro-radiographs and sagittal histologic sections, from the center of the mandible, were evaluated by computer morphometrics (%bone fill) and by a semi-quantitative bone formation score. Mean percent area of new bone was 12.4% (0–25.9%), 7.5% (0–21.3%) and 3.8% (0–10.5%) in mandibles distracted at 1, 2 or 4 mm/day respectively. At all time points, percent area of new bone was highest in mandibles distracted at 1 mm/day. Bone was deposited from the margins of the osteotomy toward the center of the wound and occurred first around the inferior alveolar canal and tooth bud regions. New bone formed by intramembranous ossification alone. The results of this experiment document the contribution of endosteal bone formation in this model of distraction osteogenesis.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2004.09.002