pH-Controllable drug release using hydrogel encapsulated mesoporous silica

Amine-functionalized mesoporous SBA-15 silica loaded with bovine serum albumin (BSA) has been successfully encapsulated with a thin layer coating of poly(acrylic acid) PAA, with the entrapped BSA being released from the PAA-encapsulated SBA-15 at the higher pH value of 7.4 rather than at the lower p...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2007-11 (42), p.4396-4398
Main Authors: Song, S-W, Hidajat, K, Kawi, S
Format: Article
Language:English
Subjects:
Acrylic Resins - chemistry
Circular Dichroism
Drug Compounding - methods
Drug Delivery Systems
Hydrogels - chemistry
Hydrogen-Ion Concentration
Microscopy, Electron, Transmission
Pharmaceutical Preparations - chemistry
Proteins - chemistry
Serum Albumin, Bovine - chemistry
Silicon Dioxide - chemistry
Tetrazolium Salts
Thiazoles
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Summary:Amine-functionalized mesoporous SBA-15 silica loaded with bovine serum albumin (BSA) has been successfully encapsulated with a thin layer coating of poly(acrylic acid) PAA, with the entrapped BSA being released from the PAA-encapsulated SBA-15 at the higher pH value of 7.4 rather than at the lower pH value of 1.2. This novel drug delivery system has a potential application in the release of protein drug to the site of higher pH value, such as small intestine or colon.
ISSN:1359-7345
DOI:10.1039/b707626f