Detection of telomerase activity in saliva from oral squamous cell carcinoma patients

Tumor markers have been detected in saliva from patients with oral cancers. In order to investigate the expression of telomerase in saliva and its clinical significance. Sixty-two saliva specimens were collected from 32 patients with oral squamous cell carcinoma and 30 normal persons, the telomerase...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2005-07, Vol.34 (5), p.566-570
Main Authors: Zhong, L.-P., Chen, G.-F., Xu, Z.-F., Zhang, X., Ping, F.-Y., Zhao, S.-F.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - analysis
Carcinoma, Squamous Cell - enzymology
Carcinoma, Squamous Cell - secondary
Dentistry
Female
Humans
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Mouth Neoplasms - enzymology
Neoplasm Staging
oral squamous cell carcinoma
Otorhinolaryngology. Stomatology
polymerase chain reaction
saliva
Saliva - enzymology
Telomerase - analysis
telomerase activity
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Tumor markers have been detected in saliva from patients with oral cancers. In order to investigate the expression of telomerase in saliva and its clinical significance. Sixty-two saliva specimens were collected from 32 patients with oral squamous cell carcinoma and 30 normal persons, the telomerase activity was assayed by telomerase PCR-ELISA method. It was detected positively in 75.0% (24/32) of patients with oral squamous cell carcinoma, while it was positive in 6.67% (2/30) of normal persons, the statistical difference was significant with P < 0.001. But the difference of expression of telomerase activity between the patients in clinical early and late stage was not significant with P > 0.05, the same to that between the patients with and without lymph nodes metastasis with P > 0.05. The results suggest that the telomerase in saliva could be used as an assistant marker for oral squamous cell carcinoma, however, a larger study is encouraged to confirm the value of judgement on clinical stage and lymph nodes metastasis.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2004.10.007