Metabolic syndrome and urinary cGMP excretion in general population

Abstract To examine the relationship between metabolic syndrome and endothelial dysfunction, we investigated cross-sectionally the correlation between metabolic risk factors and urinary excretion of cyclic guanosine 3′,5′-monophosphate (cGMP), a second messenger of nitric oxide (NO), in 1541 Japanes...

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Bibliographic Details
Published in:Atherosclerosis 2007-02, Vol.190 (2), p.423-428
Main Authors: Cui, Renzhe, Iso, Hiroyasu, Pi, Jingbo, Kumagai, Yoshito, Yamagishi, Kazumasa, Tanigawa, Takeshi, Shimamoto, Takashi
Format: Article
Language:English
Subjects:
Adult
Aged
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Biomarkers - urine
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiovascular
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - urine
cGMP
Cross-sectional studies
Cyclic GMP - urine
Endothelium, Vascular - physiopathology
Female
Health Surveys
Humans
Injuries of the limb. Injuries of the spine
Japan - epidemiology
Male
Medical sciences
Metabolic syndrome
Metabolic Syndrome - epidemiology
Metabolic Syndrome - physiopathology
Metabolic Syndrome - urine
Middle Aged
Nitric oxide
Risk Factors
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Traumas. Diseases due to physical agents
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Summary:Abstract To examine the relationship between metabolic syndrome and endothelial dysfunction, we investigated cross-sectionally the correlation between metabolic risk factors and urinary excretion of cyclic guanosine 3′,5′-monophosphate (cGMP), a second messenger of nitric oxide (NO), in 1541 Japanese men and women aged 40–79 years. The 24-h urinary excretion of cGMP was measured using a125 I-labeled cGMP radioimmunoassay and was adjusted for urinary creatinine excretion (nmol/mmol creatinine). The components of metabolic syndrome were defined based on the following criteria: body mass index (BMI) ≥ 25.0 kg/m2 , fasting plasma glucose ≥ 6.11 mmol/l or non-fasting plasma glucose level ≥ 11.1 mmol/l, systolic blood pressure ≥ 130 mm Hg or diastolic blood pressure ≥ 85 mm Hg, high-density lipoprotein (HDL)-cholesterol < 1.03 mmol/l for men and
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2006.02.032