Peripheral neuroblastic tumours in eastern Denmark 1972-2002

The peripheral neuroblastic tumour group includes neuroblastoma, ganglioneuroblastoma and ganglioneuroma. Neuroblastoma is the most common extracranial solid tumour of childhood. We have evaluated the histological presentation, MYCN gene status, and clinical course of peripheral neuroblastic tumours...

Full description

Saved in:
Bibliographic Details
Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2007-01, Vol.115 (1), p.66-74
Main Authors: ZIMLING, ZARAH GLAD, RECHNITZER, CATHERINE, RASMUSSEN, MARIANNE, PETERSEN, BODIL LAUB
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers, Tumor - analysis
Denmark
Female
Fundamental and applied biological sciences. Psychology
ganglioneuroblastoma
ganglioneuroma
Humans
Infectious diseases
Male
Medical sciences
Microbiology
Middle Aged
MYCN
N-Myc Proto-Oncogene Protein
Neuroblastoma
Neuroblastoma - diagnosis
Neuroblastoma - genetics
Neuroblastoma - pathology
Nuclear Proteins - genetics
Oncogene Proteins - genetics
Prognosis
Retrospective Studies
survival
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The peripheral neuroblastic tumour group includes neuroblastoma, ganglioneuroblastoma and ganglioneuroma. Neuroblastoma is the most common extracranial solid tumour of childhood. We have evaluated the histological presentation, MYCN gene status, and clinical course of peripheral neuroblastic tumours diagnosed and treated in eastern Denmark from 1972–2002. 125 patients were diagnosed with peripheral neuroblastic tumour during this 30‐year period. The histological material was reviewed and classified into three categories in accordance with the Shimada system: unfavourable histology, favourable histology, and benign tumours. MYCN status was determined by fluorescent in situ hybridization (FISH) on paraffin sections from the primary tumour. Clinical information was obtained from hospital records. Diagnostic likelihood ratios in the two groups were calculated to compare the ability of MYCN status and histological classification to predict 5‐year outcome. 41 tumours showed unfavourable histology, 30 tumours showed favourable histology, 11 were benign, and 43 were unclassifiable due to limited amounts of primary tumour, bad preservation or inaccessibility of the primary tumour necessitating metastatic tumour biopsy for diagnosis. Unfavourable histology was associated with widespread disease (p
ISSN:0903-4641
1600-0463
DOI:10.1111/j.1600-0463.2007.apm_355.x