Total hearing loss and blindness caused by relapsing polychondritis and myelodysplastic syndrome

Relapsing polychondritis is an autoimmune disease that primarily manifests as cartilaginous tissue destruction. However, the immune impairment may also involve noncartilaginous tissues such as kidneys, blood vessels, etc. The disease may occur as a primary disorder or in association with other disea...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2007-12, Vol.264 (12), p.1517-1519
Main Authors: COHA, Bozena, FUSTAR-PRERADOVIC, Ljubica, SEKELJ, Sandra, SEKELJ, Alen
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blindness - etiology
Deafness - etiology
Diseases of the osteoarticular system
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Female
Humans
Inflammatory joint diseases
Medical sciences
Middle Aged
Myelodysplastic Syndromes - complications
Myelodysplastic Syndromes - diagnosis
Myelodysplastic Syndromes - therapy
Non tumoral diseases
Ophthalmology
Otorhinolaryngology. Stomatology
Polychondritis, Relapsing - complications
Polychondritis, Relapsing - diagnosis
Polychondritis, Relapsing - therapy
Vision disorders
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Summary:Relapsing polychondritis is an autoimmune disease that primarily manifests as cartilaginous tissue destruction. However, the immune impairment may also involve noncartilaginous tissues such as kidneys, blood vessels, etc. The disease may occur as a primary disorder or in association with other diseases. The case of a female patient with concurrent manifestation of myelodysplastic syndrome-refractory anemia with excess blasts, and relapsing polychondritis, is presented. The diagnosis of relapsing polychondritis was established ten months after the diagnosis of myelodysplastic syndrome, when the criteria for the former were met. Total hearing loss and blindness developed soon thereafter.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-007-0387-9