Does the polymorphism of MHC class II promoters matter?

The promoters of genes of the major histocompatibility complex vary not only because of linkage disequilibrium with their coding sequences but also, we argue, because of natural selection that acts particularly strongly on MHC II gene promoters. Thus, the promoter of H2Eb varies more than that of H2...

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Bibliographic Details
Published in:Cellular immunology 2005-02, Vol.233 (2), p.162-165
Main Authors: Mitchison, N.A., Ono, S.J., Stephens, H.A.
Format: Article
Language:English
Subjects:
Animals
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - immunology
Humans
Lentivirus
MHC
Polymorphism
Polymorphism, Genetic
Promoter
Promoter Regions, Genetic
Transduction
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Summary:The promoters of genes of the major histocompatibility complex vary not only because of linkage disequilibrium with their coding sequences but also, we argue, because of natural selection that acts particularly strongly on MHC II gene promoters. Thus, the promoter of H2Eb varies more than that of H2K, to an extent that cannot be accounted for by coding variation, and the same applies to HLA.DRB1 in comparison with H2D. We discuss how transduction by lentivirus vectors followed by adoptive transfer of monoclonal T cells could be used to test the functional activity of variant mouse promoters in vivo, and how homologous recombination in suitable cell lines might provide a short cut to obtaining promoter knock-ins.
ISSN:0008-8749
1090-2163
DOI:10.1016/j.cellimm.2005.04.014