Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?

Relative to other neutral amino acid transporters, the expression levels of ASCT2 and LAT1, are coordinately elevated in a wide spectrum of primary human cancers, suggesting that they are frequently co-opted to support the “tumor metabolome”. Each has recently been shown to play important roles in t...

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Bibliographic Details
Published in:Seminars in cancer biology 2005-08, Vol.15 (4), p.254-266
Main Authors: Fuchs, Bryan C., Bode, Barrie P.
Format: Article
Language:English
Subjects:
Amino Acid Transport System ASC - metabolism
ASCT2
Biological Transport
Cancer
Humans
Large Neutral Amino Acid-Transporter 1 - metabolism
LAT1
Minor Histocompatibility Antigens
mTOR
Neoplasms - metabolism
Neoplasms - pathology
Protein Kinases - metabolism
TOR Serine-Threonine Kinases
Transport
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Summary:Relative to other neutral amino acid transporters, the expression levels of ASCT2 and LAT1, are coordinately elevated in a wide spectrum of primary human cancers, suggesting that they are frequently co-opted to support the “tumor metabolome”. Each has recently been shown to play important roles in the growth and survival of cancer cell lines, making them potential targets for cancer therapy. The properties and putative relationship of these two amino acid exchangers are discussed in the context of their demonstrated utility in cancer biology, including cellular growth and survival signaling and integrated links to the mammalian target-of-rapamycin (mTOR) kinase.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2005.04.005