Spatial learning and long-term potentiation of mutant mice lacking d-amino-acid oxidase

We evaluated the role of d-amino-acid oxidase on spatial learning and long-term potentiation (LTP) in the hippocampus, since this enzyme metabolizes d-amino-acids, some of which enhance the N-methyl- d-aspartate receptor functions. The Morris water maze learning and the LTP in the CA1 area of the hi...

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Bibliographic Details
Published in:Neuroscience research 2005-09, Vol.53 (1), p.34-38
Main Authors: Maekawa, Masao, Watanabe, Masashi, Yamaguchi, Shigeki, Konno, Ryuichi, Hori, Yuuichi
Format: Article
Language:English
Subjects:
6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology
Analysis of Variance
Animals
Behavior, Animal - physiology
CA1 area
d-Alanine
D-Amino-Acid Oxidase - deficiency
d-Serine
Electric Stimulation - methods
Excitatory Amino Acid Antagonists - pharmacology
Excitatory Postsynaptic Potentials - drug effects
Excitatory Postsynaptic Potentials - physiology
Excitatory Postsynaptic Potentials - radiation effects
Hippocampus
Hippocampus - drug effects
Hippocampus - physiology
Hippocampus - radiation effects
In Vitro Techniques
Learning - drug effects
Learning - physiology
Learning - radiation effects
Long-Term Potentiation - drug effects
Long-Term Potentiation - genetics
Long-Term Potentiation - radiation effects
LTP
Male
Maze Learning - physiology
Membrane Potentials - drug effects
Membrane Potentials - physiology
Membrane Potentials - radiation effects
Mice
Mice, Knockout
NMDA receptor
Patch-Clamp Techniques - methods
Plasticity
Pyramidal Cells - drug effects
Pyramidal Cells - radiation effects
Spatial Behavior - drug effects
Spatial Behavior - physiology
Spatial Behavior - radiation effects
Swimming - physiology
Water maze
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Summary:We evaluated the role of d-amino-acid oxidase on spatial learning and long-term potentiation (LTP) in the hippocampus, since this enzyme metabolizes d-amino-acids, some of which enhance the N-methyl- d-aspartate receptor functions. The Morris water maze learning and the LTP in the CA1 area of the hippocampal slice were observed in wild-type mice and mutant mice lacking d-amino-acid oxidase. The mutant mice showed significantly shorter platform search times in the water maze and significantly larger hippocampal LTPs than the wild-type mice. These results suggest that the abundant d-amino-acids in the mutant mouse brain facilitate hippocampal LTP and spatial learning.
ISSN:0168-0102
1872-8111
DOI:10.1016/j.neures.2005.05.008