Endothelial function in patients with vasculogenic erectile dysfunction

Erectile dysfunction (ED) commonly coexists with coronary artery disease (CAD) and/or risk factors for atherosclerosis. Because the silent or documented atherosclerosis or vascular risk factors are very frequent, the possibility of endothelial dysfunction in ED patients is expected to be increased....

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Bibliographic Details
Published in:International journal of cardiology 2005-08, Vol.103 (1), p.19-26
Main Authors: Yavuzgil, Oğuz, Altay, Barış, Zoghi, Mehdi, Gürgün, Cemil, Kayıkçıoğlu, Meral, Kültürsay, Hakan
Format: Article
Language:English
Subjects:
Arteriosclerosis - complications
Arteriosclerosis - physiopathology
Biological and medical sciences
Blood Flow Velocity - drug effects
Blood Flow Velocity - physiology
Brachial Artery - diagnostic imaging
Brachial Artery - physiopathology
Cardiology. Vascular system
Cross-Sectional Studies
Endothelial dysfunction
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiopathology
Erectile dysfunction
Flow-mediated dilatation
Humans
Impotence, Vasculogenic - diagnostic imaging
Impotence, Vasculogenic - etiology
Impotence, Vasculogenic - physiopathology
Male
Medical sciences
Middle Aged
Nitroglycerin - pharmacology
Retrospective Studies
Risk Factors
Ultrasonography, Doppler, Duplex
Vasodilation - drug effects
Vasodilation - physiology
Vasodilator Agents - pharmacology
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Summary:Erectile dysfunction (ED) commonly coexists with coronary artery disease (CAD) and/or risk factors for atherosclerosis. Because the silent or documented atherosclerosis or vascular risk factors are very frequent, the possibility of endothelial dysfunction in ED patients is expected to be increased. Our aim was to evaluate the endothelial functions in patients with vasculogenic ED with vascular risk factors and compare them with age-matched non-ED patients or healthy controls. We studied 36 patients with presumed vasculogenic ED, 39 age-matched patients with similar risk factors without ED and 25 age-matched healthy controls without ED, known cardiovascular disease or risk factors. Erectile function was evaluated by the International Index of Erectile Dysfunction (IIEF) scores. Brachial artery flow-mediated dilatation (FMD) and nitroglycerine-mediated dilatation (NMD) were measured. Baseline demographics were similar except the IIEF score and duration of diabetes in patients with ED. Brachial artery FMD and NMD were significantly reduced in patients with ED (3.2±3. vs. 6±4, p
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2004.07.004